The half-life of Xanax in people who are obese is higher than average. It ranged between 9. Studies have found that the half-life of Xanax is increased by 25 percent in Asians compared to Caucasians.
A higher basal metabolic rate may decrease the time it takes for Xanax to leave the body. People who exercise regularly or have faster metabolisms may be able to excrete Xanax faster than people who are sedentary. It takes longer for people with alcoholic liver disease to break down, or metabolize, Xanax.
On average, the half-life of Xanax in people with this liver problem is Each tablet of Xanax contains 0. In general, higher doses will take longer for your body to fully metabolize.
People who have been taking Xanax on a regular basis will consistently maintain a higher concentration in their bloodstream. This means that the effects of Xanax will last longer.
On the other hand, certain medications help to induce, or speed up the process, of CYP3A. These medications will make your body break down Xanax even faster.
An example is the seizure medication carbamazepine Tegretol and an herbal remedy known as St. Alcohol and Xanax taken in combination have a synergistic effect on one another. This means that the effects of Xanax are increased if you consume alcohol.
It will take longer to clear Xanax from your body. Combining alcohol with Xanax can lead to dangerous side effects , including the possibility of a fatal overdose. These may include:. Instead, the dosage should be reduced gradually over time to prevent withdrawal. This is called tapering. For panic disorders, the dosage of Xanax is often greater than 4 mg per day.
This can lead to severe physical and emotional dependence and make it much more difficult to taper treatment. Your doctor will help you discontinue Xanax in a careful and safe way. Xanax should fully clear the body in less than four days for most healthy individuals.
However, there are a number of factors that could alter the time it takes for Xanax to clear the body, including age, race, weight, and dose. Do not stop taking alprazolam abruptly, and do not make any changes to therapy without consulting your health care provider. Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists.
This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein.
The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Search Close Menu. Sign In About Mental Illness. About Mental Illness Treatments. About Mental Illness Research. Your Journey Individuals with Mental Illness. Your Journey Family Members and Caregivers. Your Journey Identity and Cultural Dimensions. Your Journey Frontline Professionals.
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Mental health conditions Learn more about common mental health conditions that affect millions. Other symptoms include: Restlessness Fatigue low energy, feeling tired all the time Difficulty concentrating Irritability Muscle tension Sleep disturbance difficulty falling asleep or waking up in the middle of the night Panic Disorder occurs when a person experiences unexpected and repeated episodes of intense fear.
When starting alprazolam, anxiety or insomnia may improve rapidly or over a period of days. Avoid alcohol while taking this medication. Regarding breastfeeding, caution is advised since alprazolam does pass into breast milk. Symptoms of your condition that bother you the most If you have thoughts of suicide or harming yourself Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects If you experience side effects from your medications, discuss them with your healthcare provider.
Some side effects may pass with time, but others may require changes in the medication. Any other psychiatric or medical problems you have including obstructive sleep apnea All other medications you are currently taking including over the counter products and herbal and nutritional supplements and any medication allergies you have Other non-medication treatment you are receiving such as talk therapy or substance abuse treatment. Your provider can explain how these different treatments work with the medication If you are elderly or are prone to falls If you are pregnant, plan to become pregnant, or are breast-feeding If you have liver disease If you drink alcohol or use drugs How Should I Take Alprazolam?
The main advantage of the new extended-release formulation appears to be its greater tolerability and safety. The speed with which high-potency benzodiazepines are absorbed, and rise to peak concentrations is correlated with both abuse potential and with the incidence and severity of common adverse events, such as sedation and cognitive and psychomotor impairment.
Alprazolam-XR does not exhibit the sudden increases in plasma concentration characteristic of the original formulation of alprazolam. This pharmacokinetic difference appears to translate into a reduced liability of abuse and a reduced incidence of sedation and cognitive and psychomotor impairment during acute therapy.
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